Background: Hyperemesis gravidarum (HG) represents a more severe degree of nausea and vomiting of pregnancy and is potentially lethal if not treated well. HG is defined as persisting nausea and vomiting leading to dehydration, weight loss and nutritional deficiencies and was reported to be associated with poor perinatal outcome. Aim: To evaluate the effect of HG on the perinatal outcome. Patients and Methods: The study was conducted at Suez Canal University Hospitals, Ismailia at outpatient clinic from October 2015 to January 2017. 132 patients were randomly selected with evidence of HG, the study group, and 137 women with no evidence of HG were the control group. Preterm birth, low birth weight, Apgar score Results: The Apgar score at 5 minutes of birth was the only outcome showed significant difference between the both groups (P value <0.001) while other mentioned perinatal outcomes were of insignificant difference. Also such significant difference in the Apgar score was more related to the maternal weight gain. Conclusion: Apgar score at 5 minutes of birth could be affected by HG if associated with poor maternal weight gain
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