Metformin Plus Myoinositol Versus Metformin in Polycystic Ovarian Syndrome Women Undergoing Ovulation Induction with Letrozole

Document Type : Original Article

Authors

1 Obstetrics and gynaecology Alexandria University

2 Department of Obstetrics and Gynecology, Alexandria University

3 Deprtment of obstetrics and gynaecology Alexandria University

Abstract

Objectives: To assess the effect of combined metformin and myo- inositol in comparison to metformin alone on the ovarian response and improving insulin resistance parameters in PCOS infertile women undergoing induction of ovulation.
Study design: This study was a randomized controlled study conducted for a minimal total number of 60 eligible study patients (30 per group). Women were recruited from a routine infertility clinic.
Results: This study was a randomized controlled study conducted for a minimal total number of 60 eligible study patients (30 per group). Women were recruited from a routine infertility clinic. As regards pregnancy rate, the pregnancy rate was lower in group 2 than group 1 but there was not any statistically significant difference between the groups (p= 0.162). As regards ovarian response, there was not no statistically significant difference between the studied groups at the beginning of the study after the first cycle of ovulation induction (p= 0.706). As regards ovarian response, the ovarian response at the end of the study after the second cycle of ovulation induction was higher in group 1 (Myo-inositol 600 mg+Metformin 500 mg+Folic acid) than in group 2 (Metformin 500mg), which is statistically significant (p= 0.002).
Conclusion: From this study, we conclude that: -The ovarian response was notably higher in myo-inositol plus metformin group than in the metformin group. - There was a higher pregnancy rate in myo-inositol plus metformin group, but there was no statistically notable difference between the two groups.

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