Correlation of Anti-mullerian Hormone (AMH) and Thyroid Stimulating Hormone (TSH) in Patients with Polycystic Ovary Syndrome

Document Type : Original Article

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Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt

Abstract

Background: PreeclampsiaPolycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age. The prevalence of PCOS is variable between different populations and ranged from 6% to 13%. It is a syndrome of ovarian dysfunction (oligo-ovulation or anovulation) along with the cardinal features of hyperandrogenism or hyperandrogenemia and Polycystic Ovary morphology (PCO) by ultrasound. Thyroid dysfunction is associated with Polycystic Ovary Syndrome (PCOS) in women of reproductive age. Anti-Müllerian hormone (AMH), a known biomarker of ovarian function, may be affected by impaired thyroid function; however, the relationship between AMH and thyroid stimulating hormone has not been elucidated.
Aim: To establish a correlation between Thyroid Stimulating Hormone and Anti-Mullerian Hormone in patients with PCOS.
Methods: In this study, we recruited 120 Egyptian females diagnosed as PCOS by Rotterdam’s criteria from October 2018 to March 2019. Patients aged 20-40 years were included in the study. Patients with known chronic illness or autoimmune diseases as systemic lupus erythematosus (SLE), rheumatoid arthritis were excluded from the study. Patients who underwent thyroid operations, e.g. total or partial thyroidectomy, were also excluded. We assessed patients’ Age, BMI, FSH, LH, E2, TSH, FT3, FT4, AMH as independent variables. Patients were monitored by transvaginal ultrasound examination to evaluate the antral follicular count.
Results: AMH levels were positively correlated with TSH level (p-value 0.014), however; it is weak correlation. There was a strong correlation between AMH concentration and AFC (p-value<0.001).
Conclusion: There is a weak positive correlation between AMH and TSH in women of reproductive age with PCOS.

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