Evaluation of Urinary Calcium Creatinine Ratio in Preeclampsia at Mansoura University Hospitals

Document Type : Original Article

Authors

obstetric and gynaecology ,faculty of medicine ,Mansoura university

Abstract

Background: Preeclampsia is a multisystem hypertensive condition of gestation related to significant neonatal and maternal morbidity. Identifying early predictors remains a priority for improving outcomes. The urinary calcium/creatinine ratio (UCCR) has been suggested as a non-invasive tool for this purpose.
Aim: To assess the urinary calcium/creatinine ratio (ca/cr ratio) in women had preeclampsia compared to normotensive pregnancies and correlate UCCR levels with the degree of preeclampsia.
Patients and Methods: This cross-sectional case-control research involved 102 pregnant women at twenty weeks or more of gestation, separated into 3 groups: Group A (normotensive controls), Group B (mild preeclampsia), and Group C (severe preeclampsia), with 34 participants in each group. All participants underwent history taking, clinical assessment, laboratory tests, and UCCR evaluation from midstream urine samples.
Results: Median UCCR values were significantly lower in preeclampsia groups: 0.03 in mild and 0.02 in severe cases versus 0.18 in normotensive controls (p<0.001). UCCR showed strong discriminatory power with cut-off values of≤0.095 for mild and≤0.155 for severe preeclampsia (AUC= 0.841 and 0.875, respectively). Positive correlations were found between UCCR and BMI (p= 0.01) in controls, gravidity in mild cases (p= 0.04), and platelet count in severe cases (p= 0.017).
Conclusion: Urinary calcium/creatinine ratio is significantly decreased in preeclampsia and correlates with disease severity. It serves as a simple, cost-effective, and reliable screening tool for early prediction of preeclampsia.

Keywords

Main Subjects

Files

Share

How to cite

Statistics