White Blood Cells Parameters in Normal Pregnancy and Severe Preeclampsia

Elmarghany, Iman Mohamed; Abo El Kheir, Nermin; Abdelrazik, Mahmoud M.; Mesbah, Yasser M.; Elesawi, Maher

doi:10.21608/ebwhj.2025.363871.1437

White Blood Cells Parameters in Normal Pregnancy and Severe Preeclampsia

Document Type : Original Article

Authors

¹ obstretics and gynaecology department ,faculty of medicine ,mansoura university ,mansoura ,egypt

² Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt

³ Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Egypt.

10.21608/ebwhj.2025.363871.1437

Abstract

Background: Preeclampsia (PE) is a hypertensive disorder in pregnancy (HDP) with different theories about aetiology and pathophysiology. The actual cause of PE is not well-identified. Recently, it has been believed that leukocyte stimulation has a considerable role in PE pathogenesis.
Aim: To detect the different changes in parameters of WBCs in normal pregnancy and severe PE.
Methods: This prospective study included 70 pregnant women during the third trimester of gestation. Cases were divided into two groups; the Preeclampsia group comprised 35 pregnant women who were clinically and pathologically confirmed with severe preeclampsia (SPE), and their blood was drawn in the antenatal period. In contrast, the control group included 35 non-preeclamptic pregnant females. All patients were subjected to entire history taking, clinical examination, ultrasound examination and laboratory investigations, including complete blood count (CBC).
Results: A statistically significant difference was recorded between both groups regarding gestational age (GA), mean SBP, mean DBP, HB, serum creatinine, SGOT, albumin, INR, neutrophils, monocytes and basophils. There was a non-statistically significant difference between the two studied groups concerning white blood cell (WBC) count, lymphocytes and Eosinophils. There was a substantial correlation between WBC count and serum creatinine.
Conclusion: This study demonstrated significantly increased values of neutrophils, monocytes, and basophils in PE compared to the control group. Therefore, regular follow-up of haematological parameters could be utilized as indicators in assessing PE severity and could be considered a helpful parameter for preventing PE-related adverse events.

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