Clinical Assessment of the Effect of Intravenous Tranexamic Acid in Decreasing Blood Loss During Elective Cesarean Section

Document Type : Research High lights

Authors

1 Department of Obstetrics and Gynecology, College of Medicine, Misr University for Science and Technology(MUST)

2 Ahmed farid elshazly

3 obstetrics and gynaecology department Misr University for science and technology 6th October

Abstract

Objective: Determine the effectiveness and protection of tranexamic acid (TXA) in minimizing blood loss before and after cesarean section (CS).
Study Design: A Non-randomized controlled study. In University Hospitals the period from December 2019 to July 2020.
Methodology: This study was conducted on 220 patients attending to labor ward for elective cesarean section. The patients were divided into two groups(study group and control group) 110 women in each. The study group received injection of 1 gm. of TXA while the control group received 10 ml. of normal saline 10 minutes before the surgery. Blood loss was measured by equation calculating the differences between pre- and 24 hrs. post-operative hematocrit values of each patient.
Results: Tranexamic acid significantly reduced the quantity of total blood loss which was 647.93±155.0 ml in the TXA group versus 773.79±141.7 ml in the control group (p < 0.001). The proportion of women in the TXA group who had an estimated blood loss >1000 mL was significantly lower than in the control group [2 (1.8%) versus 9 (8.2%), respectively]; and there were no significant differences between both group as regards the need for additional uterotonic agents nor blood transfusion . Furthermore, no episode of thrombosis was reported in the study. No complications or side effects were reported in either group.
Conclusion: Tranexamic acid significantly reduced the amount of total blood loss during cesarean section. Its use was not associated with any side effects or complication like thrombosis. TXA can be used safely and effectively in women undergoing LSCS.

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