Obstetric and Perinatal Outcomes After Fresh Embryo Transfer Versus Frozen-Thawed Embryo Transfer With Artificial Hormonal Endometrial Preparation: A Prospective Non-Randomized Study

Shoukry, Ahmed; ElKassar, Yasser; Hammad, Mahmoud A.; Toppozada, Tarek

doi:10.21608/ebwhj.2024.301289.1338

Obstetric and Perinatal Outcomes After Fresh Embryo Transfer Versus Frozen-Thawed Embryo Transfer With Artificial Hormonal Endometrial Preparation: A Prospective Non-Randomized Study

Document Type : Original Article

Authors

¹ Department of Obstetrics &amp; gynecology, Faculty of Medicine, Alexandria University

² Department of Obstetrics & Gynecology, Faculty of Medicine, Alexandria University, Egypt

³ Maternity Hospital, Alexandria, Egypt

10.21608/ebwhj.2024.301289.1338

Abstract

Background: It is known that obstetric outcomes in singleton ICSI pregnancies are worse than those after spontaneous conceptions. With regard to maternal complications, some studies had showed that FET was associated with lower risks of placenta previa and PTB than fresh ET. On the other hand, FET may contribute to an increased risk of preeclampsia and GDM.
Objective: The aim of this study was to analyze the obstetric and perinatal outcomes in singleton pregnancies achieved after fresh ET versus FET.
Patients & Methods: Prospective cohort, non-randomized study was conducted for 130 eligible singleton pregnant women after a fresh ET (Group A) or a FET (Group B). All the cases in the two study groups were subjected to detailed history taking, antenatal care visits, 2nd trimester fetal anatomical scan, and 3rd trimester fetal Doppler evaluation. All cases were followed up till delivery and development of any obstetric/perinatal complications was observed and managed accordingly.
Results: Regarding the obstetric outcomes that were developed through the pregnancy period include, showed no statistical significance in the group of FET in comparison with the fresh ET group. Also both groups were similar as regards CS rate, mean GA at delivery, and mean neonatal birthweight, and percentage of NICU admission. There was a slight difference in Agpar score at 1 & 5 minutes between the two groups, toward a higher score in the fresh group (p=0.032).
Conclusion: Pregnancies arise after FET show comparable outcomes, so freeze all & FET policy could be considered - when indicated- a safe alternative approach to fresh ET.

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