Can Maternal Serum High Sensitivity C-Reactive Protein Predict Outcome of Threatened Miscarriage?

Aboshama, Rehab A; El-Nahhas, Kareem; Zaatar, Mahmoud; Abdelfattah, Laila Ezzat

doi:10.21608/ebwhj.2022.145356.1183

Can Maternal Serum High Sensitivity C-Reactive Protein Predict Outcome of Threatened Miscarriage?

Document Type : Original Article

Authors

¹ ain shams

² Department of Reproductive Health Research, National Research Centre, Egypt

³ Department of Obstetrics and Gynecology, Faculty of Medicine, Fayoum University, Egypt

10.21608/ebwhj.2022.145356.1183

Abstract

Background: Subclinical systemic inflammation may impede maternal immune tolerance, and implantation and embryonic development might be compromised. Inflammation could also be a causative factor for a proportion of miscarriages. As inflammatory reactions have a role in the occurrence of miscarriage, threatened miscarriage may be associated with higher maternal serum levels of High Sensitive - C reactive protein (HS-CRP) than in average, uncomplicated pregnancy.
Objective: To assess the accuracy of maternal serum (hs-CRP) in predicting pregnancy outcomes in women presenting with threatened miscarriage.
Study Design: Observational prospective cohort study included 200 pregnant women seeking antenatal care subdivided into two equal groups; Study group: 100 women with threatened miscarriage (presented by bleeding in early pregnancy, and Control group: 100 women with an uneventful pregnancy. All 200 pregnant women were under close follow-up every two weeks for vaginal bleeding and ultrasound assessment. For the quantitative measurement, maternal serum hs-CRP levels were evaluated by the Enzyme-Linked Immunosorbent Assay (ELISA) Kit.
Results: The mean serum level of HS-CRP (mg/dl) was significantly elevated in the study group (threatened miscarriage group) (8.73±1.55) than in the other group (5.17±2.04) in the control group (P<0.001). Miscarriage occurred in a more significant proportion in the study group (threatened miscarriage group) (40%) than their counterparts (10%) (P<0.001).
Conclusions: Maternal serum HS-CRP's levels were significantly higher in threatened miscarriage women than in average, uncomplicated pregnant women. This investigation suggests that pregnancy loss and chronic inflammation occur in association, so the relation between inflammation and pregnancy outcomes needs further investigation.

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