Effect of Using Intra-Uterine Human Chorionic Gonadotropin Before and During Embryo Transfer in Cases of Intra-Cytoplasmic Sperm Injection

Document Type : Original Article

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1 Obstetrics&Gynecology department, Benha university, Benha, Egypt

2 Department of obstetrics and gynecology, Faculty of Medicine-Benha University

3 Obstetrics & Gynecology resident, Assaf fertility center, 19 Wezaraa El Zeraa St Dokki, Egypt

Abstract

Objectives: To evaluate the effect of intrauterine injection of Human Chorionic Gonadotropin (HCG) before and during embryo transfer on pregnancy rates in women with previously failed intra-cytoplasmic sperm injection (ICSI) trials.
Study Design: Prospective observational clinical study.
Subjects and Methods: A total of 39 women with at least one previously failed IVF/ICSI trial within the last year were included in the study. HCG was prepared by dissolving 5000 IU in 5 ml of normal saline, with 1 ml of this solution used to flush the endometrium at ovum retrieval and another 1 ml mixed with embryo culture media during transfer. Fresh embryos were transferred on day 3.
Results: Thirty-six patients were analyzed. The mean age was 29 ± 4.76 years, the mean BMI was 21.95 ± 1.20, and the mean duration of infertility was 6.34 ± 3.46 years. The mean number of follicles >16 mm was 6.32 ± 4.3, endometrial thickness was 9.21 ± 2.1 mm, the number of MII oocytes was 4.21 ± 3.6, fertilized oocytes was 3.41 ± 2.5, and transferred embryos was 2.11 ± 0.2. Chemical pregnancy was achieved in 16 out of 36 patients (44.4%), and clinical pregnancy in 15 out of 16 patients (41.6%). Fourteen pregnancies progressed, with one delivery and others continuing antenatal care.
Conclusion: Intrauterine injection of HCG before and during embryo transfer appears to increase pregnancy rates in women with previous failed ICSI attempts.

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