Carbetocin versus Misoprostol in Reducing Blood Loss during Cesarean Section in low risk patients. A Randomized Controlled Trial

Moustafa, A.; Abd Elhady, S.; Shalaby, H.; Elrefaie, Waleed

doi:10.21608/ebwhj.2020.29798.1096

Carbetocin versus Misoprostol in Reducing Blood Loss during Cesarean Section in low risk patients. A Randomized Controlled Trial

Document Type : Original Article

Authors

¹ Department of Obstetrics and Gynecology, Faculty of Medicine, Nabarou Central Hospital

² Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University

³ Mansoura University, Department of Obstetrics and Gynecology, Faculty of Medicine

⁴ Departement of Obstetrics and Gynecology, Faculty of Medicine, Port Said University

10.21608/ebwhj.2020.29798.1096

Abstract

Aim: This study aimed to compare the use of misoprostol to carbetocin in reducing blood loss during cesarean section in low risk patients.
Materials and Methods: This randomized controlled study enrolled 300 patients who were eligible. 150 women received carbetocin100ug i.v intra-operative immediately after extraction of the fetus during cesarean section (group A). They were compared to 150 women who received misoprostol 600ug rectally immediately before sterilization during caesarean section (group B).
Results: There is significant difference in intraoperative uterine atony [3 (2.0%) vs 11 (7.3%) P < 0.02] and the need for blood transfusion [2 (1.2%) vs 10 (6.7%) P > 0.018] and surgical hemostatic measures as uterine artery ligation and uterine compression sutures [0.00 vs 3.00 (2%) P < 0.00 and 0.00 vs 12.00 (8%) P < 0.00] were higher in misopristol group. Also, the need for other uterotonic drugs was significantly higher in misopristol group (10.0 ± 0.0 vs 13.15 ± 5.28, P < 0.001 and the difference in hemoglobin and hematocrit values before and after delivery were slightly higher in misopristol group with no statistical significance (10.71 ± 0.98 vs 10.86 ± 0.84, P < 0.15 and 33.86 ± 2.8 vs 34.29 ± 2.7, P < 0.17).
Conclusion: Intravenous therapy infusion of 100 ug carbetocin reduced but no significantly blood loss during cesarean section than 600ug rectal misoprostol.

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