The Effect of Normalization of FSH/LH Ratio on the Response to Induction of Ovulation and Pregnancy Rate in Polycystic Ovary Syndrome Patients

Document Type : Original Article

Authors

1 Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University, Egypt

2 Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University, Egypt.

3 Faculty of medicine, Cairo University

Abstract

Objectives: To determine the role of normalization of FSH/LH ratio on the response to induction of ovulation and pregnancy 
rate in patients with polycystic ovarian disease.
Materials and Methods: This is a randomized controlled trial including 126 infertile women with PCOS attending to 
infertility clinic, Kasr Al-Ainy Maternity Hospital, Faculty of Medicine, Cairo University, from December 2021 until 
May 2022. Patients were divided into 2 equal groups:
- Group A (63 women): received OCPs for 3 successive cycles and after withdrawal bleeding of last cycle received 
clomiphene citrate 100 mg tablet orally started on 2nd day to 6th day of the cycle for five consecutive days for another 3 
cycles.
- Group B (63 women): didn’t receive pre-treatment OCPs.
Results: The rate of normalization of FSH/LH ratio after COC pills was higher in group A 51/63 (81.0%). Ovulation 
rate, endometrial thickness at the day of HCG injection and clinical pregnancy rate after induction of ovulation were 
statistically significant higher in group A compared with group B. Also, total doses of gonadotropin used and percent of 
cases needed gonadotropin using for induction of ovulation were statistically significant lower in group A compared with 
group B.
Conclusion: In infertile PCOS patients, normalization of FSH/LH ratio in by using of a short pretreatment course of 
COCs could be used as it was proved to enhance ovulation rate, endometrial thickness at the day of HCG injection and 
clinical pregnancy rate. Also, it decreases need for using and total doses of gonadotropin and its side effects.

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Evidence Based Women's Health Journal
Volume 14, Issue 1
February 2024
Pages 105-109

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