Indomethacin Prior to Difficult Embryo Transfer is it a Solution?

Document Type : Original Article

Authors

1 Obstetrics and gynecology Faculty of medicine Cairo University Cairo Egypt

2 Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University, Egypt

3 Obstetrics and gynecology , Kasr Al Aini , Cairo , Egypt

4 Obstetrics and Gynecology department, faculty of medicine, Cairo University

Abstract

Objectives: To find out the role of administration of indomethacin prior to embryo transfer in cases of difficult mock embryo transfer in in-vitro fertilization/ intra cytoplasmic sperm injection cycle in improving the reproductive outcomes.
Study Design: It is a randomized controlled trial.
Patients and Methods: The study was conducted in the in vitro fertilization units of the University hospital as well as a private unit from the 2nd of June 2018 till the 2nd of December 2018. A total of two hundred in vitro fertilization/ intra cytoplasmic sperm injection cycles who had difficult mock embryo transfer on the day of ovum pick up. Women were randomly assigned into two groups; group A (study group: n=100) will receive 100mg indomethacin rectal suppository 1-2 hours before embryo transfer, while group B (control group: n=100) did not receive any medications before the embryo transfer.
Results: Both groups were comparable regarding age, body mass index, basal hormones, and cause of infertility. The implantation (23.7% vs 20.8%, P value 0.906), clinical pregnancy (48% vs 40%, P value 0.254), and ongoing pregnancy (40% vs 36%, P value 0.560) rates were higher in the indomethacin group, but not reaching statistical significance.
Conclusion: Indomethacin, as adjuvant therapy, has no statistically significant role on in cases with difficult embryo transfer in in-vitro fertilization/ intra cytoplasmic sperm injection cycles.

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