Cervical Carcinoma in Shatby University Hospital and its Relation to Human Papilloma Virus

Document Type : Original Article

Authors

1 Obstetrics and gynecology, Faculty of medicine, Alexandria university, Alexandria, Egypt

2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt

Abstract

Objective: To detect human papilloma virus infections and its different genotypes in cervical cancer cases in Shatby obstetrics and gynecology university hospital of Alexandria medical school.
Patients and Methods: An observational analytical prospective cross-sectional study was managed on 70 cervical cancer patients collected from gyne-oncology unit in Shatby obstetrics and gynecology university hospital of Alexandria medical school. Collection of the sample from all cases of the study for human papilloma virus testing and genotyping was done.
Result: The study was conducted on 70 cervical cancer cases, considering human papilloma virus testing of the cases, the following results were found, 21 cases out of 70 cases (30%) were negative while 49 cases (70%) were positive. Collectively, 45 cases (64.3%) of the study cervical cancer cases were infected by high-risk HPV types (16,18,31), 4 cases (5,7%) by low-risk HPV types (6,11) and 21 cases (30%) were not infected.
Conclusion: The prevalence of high risk human papilloma virus positive cervical cancer cases in al Shatby Alexandria medical school university hospital was 64.3% and 55.4% of all the present study cervical cancer cases were infected by HPV types 16 and 18, the study assured the relationship between cervical cancer and high risk HPV especially types 16 and 18 and denoting the importance of HPV vaccination during adolescence and HPV testing as a screening test to detect early preinvasive cervical lesion.

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