Document Type : Original Article
Authors
1
MBBCh, Medicine and Surgery, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2
MBBCh, Medicine and Surgery, Faculty of Medicine, Cairo University, Cairo, Egypt
3
MBBCh, Medicine and Surgery, Faculty of Medicine, Alexandria University, Alexandria, Egypt
4
MBBCh, Medicine and Surgery, Faculty of Medicine, Fayoum University, Fayoum, Egypt
5
MD, Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt
Abstract
Background: Hyoscine Butylbromide (HBB) is a potent parasympatholytic drug with strong antispasmodic action contributing to cervical dilation during labor.
Objective: We aimed to determine if hyoscine butylbromide (HBB) during labor is associated with shortened duration of labor.
Search Strategy: We searched several electronic databases from inception to march 2019 using various search terms.
Selection Criteria: Randomized controlled trials comparing HBB vs. placebo regarding labor duration.
Data Collection and Analysis: After screening and data extraction, mean difference with 95% confidence interval (CI) for continuous data and odds ratio with 95% CI for categorical data were calculated.
Main Results: Fourteen articles (2287 patients) were included. HBB shortens durations of first stage (MD = -60.86, 95% CI [-82.89 to -38.84]), second stage (MD = -3.18, 95% CI [-5.12 to -1.24]) and third stage of labor (MD = -0.84, 95% CI [-1.19 to -0.50]). Indeed, overall rate of cervical dilatation was greater in HBB group (MD= 0.65-minute, 95% CI, 0.51 to 0.80). However, HBB does not affect the rate of vaginal or cesarean deliveries.
Conclusions: Hyoscine Butylbromide shortens the duration of all stages of labor and increases the rate of cervical dilatation. However, it does not affect the mode of delivery
Keywords
Main Subjects
)
View on SCiNiTO